Find HS Code and trade information for hyalosphere

Hyalosphere

A hyalosphere is a spherical structure composed of hyaluronic acid (HA). It is a relatively recent development in biomaterials science, primarily utilized in aesthetic medicine and regenerative therapies.

Material:

The core component is hyaluronic acid, a naturally occurring glycosaminoglycan found extensively in the extracellular matrix of connective tissues in humans and other animals. HA is known for its exceptional water-holding capacity, biocompatibility, and non-immunogenicity. Hyalospheres are typically created using cross-linked HA, enhancing its stability and longevity in vivo. Cross-linking methods vary, including chemical modification and physical cross-linking techniques. The degree of cross-linking influences the degradation rate and mechanical properties of the sphere.

Purpose & Function:

Hyalospheres serve multiple purposes, all stemming from the properties of HA:

• Volume Enhancement: Due to their water-absorbing capabilities, hyalospheres can add volume to tissues. This is most commonly used in dermal fillers for facial rejuvenation, lip augmentation, and wrinkle reduction.
• Tissue Support: They provide a scaffold for cellular growth and regeneration.
• Drug Delivery: Hyalospheres can be loaded with growth factors, cytokines, or other therapeutic agents, allowing for controlled release within the target tissue.
• Space Maintenance: In reconstructive surgery, they can temporarily maintain space for tissue regeneration.
• Lubrication: The viscous nature of HA contributes to lubrication of tissues, beneficial in joint injections and ophthalmic applications.

Usage Scenarios:

• Dermatology & Aesthetic Medicine: Facial fillers (nasolabial folds, marionette lines, lips, cheeks), skin hydration, scar treatment.
• Ophthalmology: Viscosupplementation for osteoarthritis, corneal repair, retinal detachment.
• Orthopedics: Treatment of osteoarthritis, cartilage regeneration.
• Wound Healing: Promotion of tissue repair and reduction of scar formation.
• Reconstructive Surgery: Soft tissue augmentation, space maintenance.
• Drug Delivery Systems: Localized delivery of therapeutic agents for cancer treatment, inflammation, or other conditions.

Common Types & Variations:

Hyalospheres are categorized based on several factors:

• Molecular Weight of HA: Different molecular weights affect viscosity, duration of effect, and cellular interactions. Low molecular weight HA penetrates tissues more easily, while high molecular weight HA provides more volume.
• Degree of Cross-linking: Higher cross-linking leads to slower degradation rates and increased mechanical stability.
• Particle Size: Varies depending on the intended application. Smaller particles are used for superficial injections, while larger particles provide deeper volume.
• Cross-linking Method: Chemical cross-linking (e.g., using BDDE) and physical cross-linking (e.g., using irradiation) result in different HA sphere characteristics.
• Formulation: Some hyalospheres contain additives like lidocaine (for pain reduction) or antioxidants.
• Loading: Some are loaded with other substances, like growth factors or proteins.

Hyalosphere, based on the provided reference material, appears to be a type of gel preparation used in human or veterinary medicine. Here's a breakdown of relevant HS codes and associated information:

• 3006700000: This HS code covers gel preparations designed for use as lubricants in surgical operations or physical examinations, or as coupling agents between the body and medical instruments. This is the most directly applicable code for hyalosphere, assuming it functions in this capacity.
  • 30: Pharmaceuticals.
  • 06: Medicaments comprising mixtures or unmixed products for therapeutic or prophylactic uses.
  • 70: Other medicaments.
• 3006400000: This HS code covers dental cements and other dental fillings, and bone reconstruction cements. While hyalosphere isn't explicitly mentioned, if the product is used in dental or bone reconstruction procedures, this code may be relevant.
  • 30: Pharmaceuticals.
  • 06: Medicaments comprising mixtures or unmixed products for therapeutic or prophylactic uses.
  • 40: Dental cements and other dental fillings; bone reconstruction cements.
• 3822190080: This HS code covers diagnostic or laboratory reagents on a backing, prepared diagnostic or laboratory reagents whether or not on a backing, whether or not put up in the form of kits, other than those of heading 3006; certified reference materials. If hyalosphere is used as a diagnostic reagent, this code could apply.
  • 38: Miscellaneous chemical products.
  • 22: Diagnostic or laboratory reagents.
  • 19: Other.
  • 00: Other.
  • 80: Other.

Regarding HS code 3006700000, please note that the product is specifically defined as being designed for use as a lubricant or coupling agent. Ensure the hyalosphere meets this definition for accurate classification.